Publications by authors named "A Amaducci"
Background: Tramadol is an adulterant of illicit opioids. As it is a serotonin-norepinephrine reuptake inhibitor as well as a μ-opioid agonist, tramadol adulteration may worsen overdose signs and symptoms or affect the amount of naloxone patients receive.
Methods: This is a multicenter, prospective cohort of adult patients with suspected opioid overdoses who presented to one of eight United States emergency departments and were included in the Toxicology Investigators Consortium's Fentalog Study.
Differences in Drug Poisonings Among Those Who Identify as Transgender Compared to Cisgender: An Analysis of the Toxicology Investigators Consortium (ToxIC) Core Registry, United States 2017-2021.
Clin Ther
December 2024
Purpose: In this manuscript, the abbreviation TG is defined as persons who identify as transgender, GNC is defined as persons who identify as gender nonconforming, and CG is defined as persons who identify as cisgender. TG and GNC (e.g.
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- Opioid overdose deaths in the U.S. have dramatically increased due to the rise of illicit fentanyl, which also raises the risk of HIV infection among those affected by injection drug use.
- A study analyzed data from 1,690 patients who experienced acute opioid overdoses across 10 hospitals to identify HIV prevalence and associated risk factors.
- The findings revealed that 5.6% of patients with known HIV status were HIV positive, with stimulant use being more common among HIV-positive individuals and a significant link found between bipolar psychiatric history and increased HIV risk.
Article Synopsis
- * A retrospective analysis of patient records was conducted, revealing that most patients were children (under 10 years old) and predominantly Hispanic, with the majority arriving at the emergency department within an hour of exposure.
- * The incident demonstrates the urgent need for CO detectors in daycares to enhance safety, provide early warnings, and improve response readiness for similar emergencies in the future.
Article Synopsis
- The American College of Medical Toxicology's Toxicology Investigators Consortium has been maintaining a national case registry since 2010, documenting patient consultations in hospitals and clinics regarding medical toxicology.
- In 2023, the registry recorded data from 7,392 patients, bringing the total number of cases since its inception to 102,331 across 36 sites with 61 healthcare facilities.
- Ethanol emerged as the most common exposure agent in 2023, followed by opioids and non-opioid analgesics, with a reported 98 fatalities (1.3% case fatality rate) and analyses of demographics and trends in toxicology consultations.