Publications by authors named "A Amadou"
Li-Fraumeni syndrome (LFS) is a heterogeneous predisposition to an individually variable spectrum of cancers caused by pathogenic germline variants. We used a clustering method to assign TP53 missense variants to classes based on their functional activities in experimental assays assessing biological p53 functions. Correlations with LFS phenotypes were analyzed using the public germline mutation database and validated in three LFS clinical cohorts.
View Article and Find Full Text PDFAssociation between chronic long-term exposure to airborne dioxins and breast cancer.
Int J Hyg Environ Health
January 2025
Article Synopsis
- Breast cancer is the most common cancer in women, and environmental pollutants, particularly endocrine disruptors like dioxins, may influence its development.
- A study analyzed the link between airborne dioxin exposure and breast cancer risk in a cohort of 5222 cases and 5222 controls, using data about their proximity to dioxin sources and other factors.
- The results indicate a slight increase in breast cancer risk with higher cumulative dioxin exposure, suggesting the need for measures to reduce air pollution exposure.
Background: Growing epidemiological evidence suggests an association between exposure to air pollutants and breast cancer. Yet, the underlying mechanisms remain poorly understood. This study explored the mediating role of thirteen metabolic health biomarkers in the relationship between exposure to three air pollutants, i.
View Article and Find Full Text PDFBackground: While genetic, hormonal, and lifestyle factors partially elucidate the incidence of breast cancer, emerging research has underscored the potential contribution of air pollution. Polychlorinated biphenyls (PCBs) and benzo[a]pyrene (BaP) are of particular concern due to endocrine-disrupting properties and their carcinogenetic effect.
Objective: To identify distinct long term trajectories of exposure to PCB153 and BaP, and estimate their associations with breast cancer risk.
Background: An increasing evidence links air pollution to breast cancer (BC) risk. Yet, pollutant exposure estimates at the workplace location in pollution exposure assessment have not been considered.
Objectives: This study investigates the association between particulate matters (PM, PM) and nitrogen dioxide (NO) atmospheric concentrations (1990-2011), at the women's residential and workplace locations, and BC risk.