Mesenchymal Stem Cell-Conditioned Media Modulate HUVEC Response to HO: Impact on Gene Expression and Potential for Atherosclerosis Intervention.

We studied the potential of human bone marrow-derived mesenchymal stem cell conditioned media (hBMSC CM) in protecting endothelial cell properties (viability, proliferation, and migrations) from the deleterious effects produced by the inflammatory environment of HO. Additionally, we investigated their impact on the endothelial cells' gene expression of some inflammatory-related genes, namely, TGF-1, FOS, ATF3, RAF-1, and SMAD3. Human umbilical vein endothelial cells (HUVECs) were cultured individually under three conditions: alone, with varying concentrations of HO, or with varying concentrations of HO and hBMSC CM.

Pharmacists' Understanding and Attitudes Toward Pharmaceutical Care in Saudi Arabia.

Background It has been proposed that pharmacy practice moves from product-focused to patient-focused. The major goals of pharmaceutical care are to improve the patient's quality of life, approve the safety of drug therapy, and seek to enhance the quality of life related to the patient's health within reasonable financial constraints. One of the biggest issues facing Saudi Arabia's healthcare system is including a pharmacist in the healthcare team who uses the most up-to-date pharmaceutical services and cares for the patient with medical and nursing care.

Using Culture Sensitivity Reports to Optimize Antimicrobial Therapy: Findings and Implications of Antimicrobial Stewardship Activity in a Hospital in Pakistan.

There are concerns with inappropriate prescribing of antibiotics in hospitals especially broad spectrum in Pakistan and the subsequent impact on antimicrobial resistance rates. One recognized way to reduce inappropriate prescribing is for empiric therapy to be adjusted according to the result of culture sensitivity reports. Using culture sensitivity reports to optimize antibiotic prescribing in a teaching hospital in Pakistan.

Impact of an educational program on community pharmacist's preparedness to conduct pharmacist-led diabetes clinic in Saudi Arabia.

Background: Demand for diabetes care and prevention has increased due to Saudi Arabia's high prevalence of diabetes mellitus and its insufficient treatment. This raised awareness of the significance of community pharmacists in Saudi Arabia, who may significantly improve diabetes treatment by setting up pharmacist-led diabetic clinics. Thus, to assess community pharmacists' readiness to lead diabetes clinics in Saudi Arabia, this study evaluated the usefulness of an educational session on diabetes care.