Publications by authors named "A Almatroudi"
Article Synopsis
- The CRISPR/Cas system is a powerful genome-editing tool used in biomedical research to manipulate genes associated with both normal and disease functions, known for its efficiency and specificity.
- Key challenges in its therapeutic applications include safe delivery to target cells and minimizing off-target effects, which can be addressed by understanding anti-CRISPR proteins (Acrs) that can inhibit the CRISPR/Cas system.
- Acrs operate through various mechanisms, and recent research on their action can enhance the safe use of CRISPR/Cas technologies, potentially leading to advancements in gene therapy, diagnostics, and antimicrobial treatments.
Unlocking the Potential of Silver Nanoparticles: From Synthesis to Versatile Bio-Applications.
Pharmaceutics
September 2024
Silver nanoparticles (AgNPs) are leading the way in nanotechnological innovation, combining the captivating properties of silver with the accuracy of nanoscale engineering, thus revolutionizing material science. Three main techniques arise within the alchemical domains of AgNP genesis: chemical, physical, and biological synthesis. Each possesses its distinct form of magic for controlling size, shape, and scalability-key factors necessary for achieving expertise in the practical application of nanoparticles.
View Article and Find Full Text PDFApigenin is a powerful flavone compound found in numerous fruits and vegetables, and it offers numerous health-promoting benefits. Many studies have evidenced that this compound has a potential role as an anti-inflammatory and antioxidant compound, making it a promising candidate for reducing the risk of pathogenesis. It has also been found to positively affect various systems in the body, such as the respiratory, digestive, immune, and reproductive systems.
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- Dengue fever is a major global health issue, causing severe symptoms and outbreaks in India, influenced by a cytokine storm and increased risk in secondary infections.
- A study in Aligarh assessed dengue prevalence and analyzed the role of specific cytokines (CXCL5, CXCL9, CCL17) in primary vs. secondary infections, finding higher levels in secondary cases.
- Identifying these cytokines early may help in diagnosing severe dengue and adjusting treatment strategies.
The genome editing approach by clustered regularly interspaced short palindromic repeats (CRISPR)/associated protein 9 (CRISPR/Cas9) is a revolutionary advancement in genetic engineering. Owing to its simple design and powerful genome-editing capability, it offers a promising strategy for the treatment of different infectious, metabolic, and genetic diseases. The crystal structure of Cas9 (SpCas9) in complex with sgRNA and its target DNA at 2.
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