Publications by authors named "A Aller"
Whole-genome characterisation of Escherichia coli isolates from patients with bacteraemia presenting with sepsis or septic shock in Spain: a multicentre cross-sectional study.
Lancet Microbe
April 2024
Article Synopsis
- - The study focuses on characterizing *Escherichia coli* (E. coli) blood isolates that cause sepsis or septic shock, as these infections are common and often severe, leading to critical health outcomes in affected patients.
- - Data from a multicenter study in Spain involved whole-genome sequencing of E. coli blood isolates from patients over 14 with diagnosed sepsis or septic shock, identifying various microbiological features, including phylogroups, sequence types, virulence factors, and antimicrobial resistance (AMR) genes.
- - Results showed that most isolates belonged to phylogenetic group 1, with specific sequence types such as ST131 and ST73 being the most common, but there were no significant geographical
Deconstructing neutrophil to lymphocyte ratio (NLR) in early breast cancer: lack of prognostic utility and biological correlates across tumor subtypes.
Breast Cancer Res Treat
June 2024
Purpose: The prognostic utility and biological correlates of neutrophil to lymphocyte ratio (NLR), a potential biomarker of the balance between immune response and the inflammatory status, are still uncertain in breast cancer (BC).
Methods: We analysed a cohort of 959 women with early breast cancer, mostly treated with neoadjuvant or adjuvant chemotherapy. Clinical and pathological data, survival, NLR (continuous and categorical) and stromal tumor infiltrating lymphocytes (sTIL) were evaluated.
Background: Goals of care conversations are essential to delivery of goal concordant care. Infrequent and inconsistent goals of care documentation potentially limit delivery of goal concordant care.
Methods: At Kaiser Permanente San Francisco Cancer Center, a standardized documentation template was designed and implemented to increase goals of care documentation by oncologists.
Advanced cancer patients benefit less from aggressive therapies and more from goal-directed palliative management. Early and clearly documented goals-of-care discussions, including end-of-life decision making, are essential in this patient population. Integrated healthcare systems are comprehensive care models associated with improved quality of care and lower mortality compared to other healthcare models.
View Article and Find Full Text PDFParacetamol (PCT), or acetaminophen, is an important drug used worldwide for various clinical purposes. However, the excessive or indiscriminate use of PCT can provoke liver and kidney dysfunction; hence, it is essential to determine the amount of this target in biological samples. In this work, we develop a quick, simple, and sensitive voltammetric method using chemically modified electrodes to determine PCT in complex matrices, including human serum and commercial solid formulations.
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