Publications by authors named "A Alkhotani"
Background: Isocitrate dehydrogenase [IDH]-wildtype glioblastoma is an aggressive brain cancer associated with high recurrence and poor overall survival.
Aim: Our study aims to explore the prognostic effects of radiotherapy [RT] alone versus concomitant RT with temozolomide [TMZ].
Methods: A multicentre retrospective study included a cohort of 244 patients diagnosed with IDH-wildtype glioblastoma, and it was analysed from 2013 to 2020.
Article Synopsis
- Hypoxic-ischemic encephalopathy (HIE) occurs in 1-2 per 1000 term live births and can lead to severe disabilities; therapeutic hypothermia is the standard treatment but can be costly, prompting exploration of low-cost alternatives like passive cooling.
- A study comparing passive cooling to active machine cooling in neonates with HIE showed similar short-term renal outcomes, with no significant differences in creatinine levels over time or in chronic kidney disease and neurodevelopmental issues long-term.
- Although results were similar, there was a slight trend of higher creatinine levels in the passive cooling group and a longer hospital stay, indicating a need for larger studies to further evaluate the impacts of these cooling methods.
Objective: At the beginning of the COVID-19 pandemic, it was recommended to provide emergency dental care and avoid aerosol-generating procedures (AGPs) when possible. This study aimed to determine how Saudi Arabian pediatric patients utilized emergency dental services at the national level at the beginning of the COVID-19 pandemic and what situations required an AGP.
Methods: Data was collected from all Ministry of Health dental facilities in Saudi Arabia between March and May 2020.
Mitochondrial DNA Alterations in Glioblastoma and Current Therapeutic Targets.
Front Biosci (Landmark Ed)
October 2024
Article Synopsis
- - Metabolic changes in tumor cells shift towards glycolysis or mitochondrial respiration depending on tumor progression, with mitochondrial dysfunction driving these changes and influencing tumor growth.
- - Mutations in mitochondrial DNA (mtDNA) have been found in tumors like glioblastoma, but many studies focus on limited parts of mtDNA, potentially missing significant mutations that affect tumor behavior.
- - Mitochondrial dysfunction impacts energy production and various signaling pathways in tumor cells, marking them as potential targets for new therapies to combat chemoresistance in glioblastoma.
Article Synopsis
- The study explored breastfeeding initiation and continuation rates among women with epilepsy at a tertiary care center in Makkah from 2019 to June 2023.
- A total of 48 women were interviewed, revealing that 68.6% practiced breastfeeding, but only 12.1% sustained it for 6 months or more, with many resorting to bottle feeding.
- Factors influencing breastfeeding included urban living, number of antiseizure medications (ASMs), seizure control during pregnancy, and type of delivery, highlighting a generally low rate of breastfeeding in this population.