Publications by authors named "A Alghisi"
Background: The standard treatment of locally advanced rectal cancers (LARC) consists on neoadjuvant chemoradiotherapy followed by total mesorectal excision. Different data in literature showed a benefit on tumor downstaging and pathological complete response (pCR) rate using radiotherapy dose escalation, however there is shortage of studies regarding dose escalation using the innovative techniques for LARC (T3-4 or N1-2).
Aim: To analyze the role of neoadjuvant radiotherapy dose escalation for LARC using innovative radiotherapy techniques.
Article Synopsis
- Secondary malignant neoplasms (SMNs) and cardiovascular diseases from cancer treatments are significant risks for early-stage Hodgkin lymphoma patients, particularly with mediastinal involvement.
- Conformal radiotherapy techniques like Intensity-Modulated Radiation Therapy (IMRT) can reduce exposure to organs-at-risk (OARs), potentially lowering long-term toxicity from treatments.
- IMRT effectively limits high-dose radiation to critical areas, but it may increase the volume of low-dose exposure, which could raise the risk of developing SMNs, emphasizing the need for personalized treatment plans that consider individual patient and disease factors.
Mesenchymal stromal cells (MSC) are attractive candidates for the treatment of acute graft versus host disease (aGvHD) or autoimmune disorders. However, mechanisms of MSC recognition remain unclear and there are evidences that MSC are not totally immunoprivileged. Data suggest that MSC undergo apoptosis after infusion in presence of cytotoxic cells and their death could drive immunosuppression.
View Article and Find Full Text PDFWe reported a successful case management of G3 skin acute dermatitis in a 32-year-old woman affected by locally advanced breast cancer underwent adjuvant chest wall irradiation. Skin acute toxicity with dry desquamation areas was treated daily with dressing medication using physiological solution, oxygen therapy and applying hyaluronic acid gauze. At the end of radiotherapy treatment, G3 skin acute dermatitis with moist desquamation was observed, so the patient continued advanced wound dressing shifted to twice weekly with physiological solution, oxygen therapy and applying hydrocolloid dressing.
View Article and Find Full Text PDFObjectives: Solitary plasmacytoma (SP) is characterized by a single mass of clonal plasma cells. Definitive RT can result in long-term local control of the SP. Due to the small number of patients and narrow range of doses, phase III randomized trials are lacking.
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