PRL1 and PRL3 promote macropinocytosis via its lipid phosphatase activity.

PRL1 and PRL3, members of the protein tyrosine phosphatase family, have been associated with cancer metastasis and poor prognosis. Despite extensive research on their protein phosphatase activity, their potential role as lipid phosphatases remains elusive. We conducted comprehensive investigations to elucidate the lipid phosphatase activity of PRL1 and PRL3 using a combination of cellular assays, biochemical analyses, and protein interactome profiling.

Towards Predicting Length of Stay and Identification of Cohort Risk Factors Using Self-Attention-Based Transformers and Association Mining: COVID-19 as a Phenotype.

Predicting length of stay (LoS) and understanding its underlying factors is essential to minimizing the risk of hospital-acquired conditions, improving financial, operational, and clinical outcomes, and better managing future pandemics. The purpose of this study was to forecast patients' LoS using a deep learning model and to analyze cohorts of risk factors reducing or prolonging LoS. We employed various preprocessing techniques, SMOTE-N to balance data, and a TabTransformer model to forecast LoS.

A Phase I, First-in-Human Study of PRL3-zumab in Advanced, Refractory Solid Tumors and Hematological Malignancies.

Background: Phosphatase of regenerating liver-3 (PRL-3) is involved in cellular processes driving metastasis, cell proliferation, invasion, motility and survival. It has been shown to be upregulated and overexpressed in cancer tissue, in contrast to low or no expression in most normal tissue. PRL3-zumab is a first-in-class humanized antibody that specifically binds to PRL-3 oncotarget with high affinity and has been shown to reduce tumor growth and increase survival.

Larval Development of the Mangrove Fiddler Crab (Kossmann, 1877) (Crustacea: Brachyura: Ocypodidae) Under Laboratory Conditions.

Larvae of the mangrove fiddler crab (Kossmann, 1877), hatched from an ovigerous female collected from the mangroves of Sumariat, Jazan Province, Saudi Arabia in the southern Red Sea, were reared in the laboratory. Four zoeal and a megalopal stages were recorded, and their morphological features are described herein for the first time. The setations of the cephalothoracic appendages of the zoeas of and their congeners exhibit several variations that help differentiate larvae of this genus easily from other meroplankton.

Preliminary Observations of the Effect of Temperature and Food Concentration on the Egg Production Rate and Hatching Success of from the Central Red Sea.

The effects of temperature and food concentration on the egg production rate (EPR) of the tropical calanoid copepod were studied from the coastal waters of the central Red Sea in March 2017. In the first experiment, adult females were incubated in glass bottles that were pre-filled with screened seawater containing a natural assemblage of phytoplankton. In the second experiment, the species were incubated in glass bottles that were enriched with different concentrations of along with natural assemblages of phytoplankton.