Publications by authors named "A Akdemir"
Introduction: Gestational diabetes mellitus (GDM) occurs on the background of increased insulin resistance. We aimed to investigate the levels of plasma pancreastatin (PST) levels and its association with metabolic, demographic, and anthropometric parameters in gestational diabetic and normal glucose-tolerant pregnant women.
Materials And Methods: A total of 165 pregnant women in the 24th-28th week of pregnancy were enrolled in this cross-sectional study.
Introduction: infects almost half of the World population. Although many infected people are symptom free, the microorganism can still cause a variety of gastrointestinal disorders and gastric adenocarcinoma. It is considered a priority pathogen for the development of new antibiotics by the World Health Organisation (WHO).
View Article and Find Full Text PDFEffect of polycystic ovary syndrome on the life quality of young women.
Rev Assoc Med Bras (1992)
May 2024
Article Synopsis
- The study assessed how polycystic ovary syndrome (PCOS) affects the quality of life in women, involving 249 participants in Istanbul from October 2022 to July 2023.
- Findings showed significant relationships between PCOS, quality of life, age, and frequent weight loss diets, revealing that women with hormone imbalance and insulin resistance experienced the most significant impact on their quality of life, while those with menstrual irregularity and fatigue were less affected.
- The conclusion emphasizes the importance of addressing the negative effects of PCOS on women's quality of life, suggesting that healthcare professionals should create tailored care plans based on the collected evidence.
Mycobacteria regulate the synthesis of mycolic acid through the fatty acid synthase system type 1 (FAS I) and the fatty acid synthase system type-2 (FAS-II). Because mammalian cells exclusively utilize the FAS-I enzyme system for fatty acid production, targeting the FAS-II enzyme system could serve as a specific approach for developing selective antimycobacterial drugs. Enoyl-acyl carrier protein reductase enzyme (InhA), part of the FAS-II enzyme system, contains the NADH cofactor in its active site and reduces the intermediate.
View Article and Find Full Text PDFIntroduction: Carbonic anhydrases (CAs) are widespread metalloenzymes with the core function of catalyzing the interconversion of CO and HCO -. Targeting these enzymes using selective inhibitors has emerged as a promising approach for the development of novel therapeutic agents against multiple diseases.
Methods: A series of novel thiosemicarbazone-containing derivatives were synthesized, characterized, and tested for their inhibitory activity against pharmaceutically important human CA I (hCA I), II (hCA II), IX (hCA IX), and XII (hCA XII) using the single tail approach.