Anatomical variations in pneumatization types and volume of sphenoid sinus in a subset of Pakistani people.

Objective: To evaluate the relationship between volume and pneumatization pattern of sphenoid sinus using computed tomography images.

Methods: The prospective, cross-sectional study was conducted at the Radiology Department of Dow University of Health Sciences, Karachi, from October 2020 to February 2021, and comprised patients of either gender aged 20-70 years who were subjected to computed tomography of paranasal sinuses. The scans were analysed for sphenoid volume and four pneumatization types of sphenoid sinus, including Type-I conchal, Type-II presellar, Type-III sellar and Type-IV postsellar.

Reusable Ni-Immobilized MOF Catalyst for Dehydrogenation of N-Heterocycles Under Milder Conditions.

Herein, we have demonstrated the design and synthesis of a novel Ni-immobilized MOF as heterogeneous catalyst for the dehydrogenation of N-heterocycles. A series of five and six-membered N-heteroarenes bearing one or more heteroatoms were synthesized in up to 98 % yield (>33 examples). Late stage functionalization to the synthesis of β-glucuronides inhibitor, antimalarial drug quinine, and the nonsteroidal anti-inflammatory drug (NSAID) indomethacin were obtained under milder reactions conditions.

Aflatoxins in cereal based products-an overview of occurrence, detection and health implication.

Aflatoxins are naturally produced toxins by specific molds, namely Aspergillus flavus and Aspergillus parasiticus. These toxins can be found in various agricultural products, including crops like maize, peanuts, cottonseed, and tree nuts. They have the potential to contaminate the food supply during different stages of production, processing, and storage.

Role of immunotherapy in gastroesophageal cancer with liver metastasis.

The role of immune checkpoint inhibitors for patients with gastroesophageal cancer with liver metastasis remains unclear. Our objective was to investigate whether immune checkpoint inhibitors are beneficial in patients with gastroesophageal cancer with liver metastasis. We searched PubMed, Embase, European Society for Medical Oncology, and American Society of Clinical Oncology meeting abstracts for phase 3 randomized clinical trials testing immune checkpoint inhibitors in metastatic/advanced gastroesophageal cancer from 2017 to 2023.

Outcomes of frail patients undergoing high-dose chemotherapy and autologous stem cell transplantation for multiple myeloma.

In patients with multiple myeloma (MM) not-eligible for autologous haematopoietic cell transplantation (autoHCT), a simplified frailty index (SFI) identifies frail patients at risk for poor outcomes, but data are limited for transplant-eligible patients. In this registry-based retrospective study, we used an adapted version of the SFI to determine the prevalence of frailty in patients ≥65 years of age with MM undergoing autoHCT. Out of 5563 patients, 37.