Publications by authors named "A Ahmadiani"
Introduction: A 40-Hz white light emitting diode (WLED) has emerged as an alternative nonpharmacological and noninvasive approach to Alzheimer disease (AD). Here, we investigated the therapeutic effects of 40-Hz WLED on psychiatric symptoms (PS) and the contribution of mitochondrial factors in the early stages of sporadic AD (sAD) in rats.
Methods: In male Wistar rats, the AD model was induced via intracerebroventricular (ICV) injection of streptozotocin (STZ).
Article Synopsis
- Alzheimer's disease (AD) is a common form of dementia, with causes linked to mitochondrial issues, oxidative stress, and ion channel problems.
- A rat study using 40 Hz flickering light therapy showed that this treatment improved cognitive function and countered biochemical changes caused by AD, like increased reactive oxygen species and amyloid beta buildup.
- The therapy also restored important mitochondrial functions, suggesting that flickering light might be a potential treatment for AD and similar neurodegenerative conditions.
Background: Alzheimer's disease (AD) is linked to the accumulation of Aβ, increased tau hyperphosphorylation, persistent neuroinflammation, and a decline in neurotrophic factors, neurogenesis, and synaptic plasticity. Oxytocin (OT) has a significant impact on memory and learning. We examined the influence of intranasal (IN) OT on synaptic plasticity, neurogenesis, histone acetylation, and spatial and cognitive memories in rats.
View Article and Find Full Text PDFGlioblastoma (GBM) is the most aggressive and lethal brain tumor. Artificial neural networks (ANNs) have the potential to make accurate predictions and improve decision making. The aim of this study was to create an ANN model to predict 15-month survival in GBM patients according to gene expression databases.
View Article and Find Full Text PDFDeciphering the lncRNA-associated competitive endogenous RNA (ceRNA) network is essential in decoding glioblastoma multiforme (GBM) pathogenesis by regulating miRNA availability and controlling mRNA stability. This study aimed to explore novel biomarkers for GBM by constructing a lncRNA-miRNA-mRNA network. A ceRNA network in GBM was constructed using lncRNA, mRNA and miRNA expression profiles from the TCGA and GEO datasets.
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