Publications by authors named "A Aguila"
Article Synopsis
- * A study measured the presence of antibodies to mosquito saliva in different macaque species across national parks, revealing high antibody levels, especially against the Culex quinquefasciatus species, indicating significant interaction with mosquito vectors.
- * The research highlights the potential for using mosquito saliva as a biomarker for studying host interactions and pathogen exposure, while also raising concerns about disease transmission between macaques, visitors, and mosquitoes in natural areas.
Point defects in crystalline solids behave as optically addressable individual quantum systems when present in sufficiently low concentrations. In two-dimensional (2D) semiconductors, such quantum defects hold potential as versatile single photon sources. Here, we report the synthesis and optical properties of Nb-doped monolayer WS in the dilute limit where the average spacing between individual dopants exceeds the optical diffraction limit, allowing the emission spectrum to be studied at the single-dopant level.
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- Photoacoustic computed tomography (PACT) is a technique that combines with ultrasound imaging to study blood flow and oxygen levels in the deep brain of small animals.
- A new device called 3D-PAULM merges these technologies for non-invasive imaging capabilities, allowing researchers to study brain functions while preserving the integrity of the skull and scalp.
- Using 3D-PAULM, researchers were able to assess the effects of ischemic stroke on mouse brains by measuring key parameters like blood perfusion, oxygen saturation, and flow velocity, which can help in understanding brain disorders.
Article Synopsis
- Lewy bodies (LBs), which are linked to Parkinson's disease (PD), can be formed in human dopaminergic neurons derived from induced pluripotent stem cells (iPSCs) when exposed to α-synuclein fibrils and immune challenges.
- Immune response factors like interferon-γ and interleukin-1β, along with activated microglia, play a critical role in promoting this inclusion formation and impair lysosomal function.
- The study suggests that LB-like inclusions may arise from disruptions in autophagy, highlighting a possible connection between immune dysfunction and PD development.
Background: Ischemic stroke elicits a complex and sustained immune response in the brain. Immunomodulatory treatments have long held promise for improving stroke outcomes, yet none have succeeded in the clinical setting. This lack of success is largely due to our incomplete understanding of how immune cells respond to stroke.
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