Publications by authors named "A Aghokeng"
Hepatitis B virus (HBV) infection leads to around 800,000 deaths yearly and is considered to be a major public health problem worldwide. However, HBV origins remain poorly understood. Here, we looked for bat HBV (BtHBV) in different bat species in Gabon to investigate the role of these animals as carriers of ancestral hepadnaviruses because these viruses are much more diverse in bats than in other host species.
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- Integrase strand transfer inhibitors (INSTIs) are now the recommended first-line treatment for HIV in low- and middle-income countries due to rising resistance to non-nucleoside reverse transcriptase inhibitors (NNRTIs).
- A study analyzed samples from West Africa and Southeast Asia to assess the prevalence of pretreatment drug resistance (PDR) to INSTIs, finding a low frequency of 1.1% while overall PDR to any drug class was significantly higher at 17.9%.
- The findings advocate for the use of INSTIs in these regions yet highlight the urgent need to prevent further drug resistance to ensure effective treatment outcomes.
Objectives: To characterize HIV drug resistance (HIVDR) below and above the WHO threshold of 1000 copies/mL, considered for the definition of HIV ART failure in resource-limited settings.
Methods: From a cohort of 280 adolescents (aged 10-19 years) receiving ART for at least 6 months, genotypic resistance testing (GRT) was attempted for two groups of participants: participants with low-level viraemia [LLV; viral load (VL) 200-999 copies/mL] and those in virological failure (VF; confirmed VL ≥1000 copies/mL) using an in-house method. The Stanford HIValg Program was used to identify relevant HIVDR mutations and predict the efficacy of the newly introduced tenofovir-lamivudine-dolutegravir combination.
Objectives: Hepatitis B virus (HBV) infection remains a public health threat in middle- and low-income countries, where mother-to-child transmission plays an important role. The aim of this study was to assess the burden of this infection among pregnant women in southern Gabon and the risk of vertical transmission.
Methods: The study was a prospective investigation conducted from April 2021 to January 2022.
Background: Achieving the UNAIDS 95% sustained viral suppression (VS) rate requires considerable global efforts, particularly among adolescents living with HIV (ALHIV) who are often associated with high rates of virological failure (VF). In this study, we prospectively assessed the rate of VS, and the factors associated with VF in a cohort of adolescents followed up according to the WHO guidelines in Cameroon.
Methods: A cross-sectional study was carried out in 2021 among adolescents (aged 10-19 years) receiving ART in the national program in Cameroon.