Publications by authors named "A Agbarya"
Background: A ground glass nodule (GGN) is a radiologically descriptive term for a lung parenchymal area with increased attenuation and preserved bronchial and vascular structures. GGNs are further divided into pure versus subsolid lesions. The differential diagnosis for GGNs is wide and contains a malignant possibility for a lung adenocarcinoma precursor or tumor.
View Article and Find Full Text PDFBackground: Impairments in higher cognitive abilities (termed executive functions (EF) are common among individuals with cancer following chemotherapy and may impact their performance of daily activities. Our aim is to better understand the changes in EF and the impact on performance in daily activities of individuals with cancer pre- and post-chemotherapy.
Methods: A convergent parallel mixed-method pre-post experimental design.
Article Synopsis
- Lung cancer is a serious disease with unique challenges, especially in patients diagnosed with resectable non-small cell lung cancer (NSCLC).
- A study from January 2022 to August 2023 involved 56 patients (mostly smokers and male) who received neoadjuvant chemo-immunotherapy before surgery, with 80% in stage III.
- Results showed 86% of patients had a positive response to treatment, and 61% had significant pathological improvements, highlighting the effectiveness of immune checkpoint inhibitors in treating NSCLC before surgery.
Article Synopsis
- A retrospective study assessed the effectiveness of crizotinib versus newer ROS1-targeted therapies in patients with advanced non-small-cell lung cancer (NSCLC).
- Among 49 ROS1-expressing patients, those treated with newer agents like entrectinib and repotrectinib had higher response and disease control rates compared to those treated with crizotinib.
- Despite crizotinib showing comparable results, the newer therapies demonstrated longer median progression-free survival, highlighting the potential benefits of newer treatment options.
Chemoresistance is a major obstacle in cancer treatment, often leading to disease progression and poor outcomes. It arises through various mechanisms such as genetic mutations, drug efflux pumps, enhanced DNA repair, and changes in the tumor microenvironment. These processes allow cancer cells to survive despite chemotherapy, underscoring the need for new strategies to overcome resistance and improve treatment efficacy.
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