Publications by authors named "A Affolter"
Head and neck squamous cell carcinoma (HNSCC) are invasive solid tumors accounting for high mortality. To improve the clinical outcome, a better understanding of the tumor and its microenvironment (TME) is crucial. Three -dimensional (3D) bioprinting is emerging as a powerful tool for recreating the TME in vitro.
View Article and Find Full Text PDFIntroduction The kinetic of C-reactive protein (CRP) in the early phase of therapy with checkpoint inhibitors (CPI) and its prognostic value has already been investigated in several tumor entities. In particular, flare dynamics have been described as a positive prognostic parameter. The aim of this retrospective study is to examine the extent to which such an application can also be transferred to patients with recurrent or metastatic squamous cell carcinoma of the head and neck region (R/M-HNSCC).
View Article and Find Full Text PDFSalivary duct carcinomas (SDC) of the parotid gland are rarely occurring highly malignant tumors. A 65-year-old man presented with a preauricular mass. After surgical treatment and histologic examination, the findings were interpreted as a squamous cell carcinoma (SCC) metastasis of the parotid gland deriving from a cancer of unknown primary DD primary SCC of the parotid gland.
View Article and Find Full Text PDFIntroduction: Checkpoint inhibitors, such as PD1 inhibitors, represent an important pillar in the therapy of advanced malignancies of the head and neck region. The most relevant complications are immune-related adverse effects (irAEs), which represent an immense burden for patients. Currently, no sufficient stratification measures are available to identify patients at increased risk of irAEs.
View Article and Find Full Text PDFArticle Synopsis
- A new 2½ D point cloud registration method was created to produce digital twins of tissue shapes and surgical cavities, utilizing machine learning to measure soft tissue shifts.
- The model was trained with data from simulated tumor resections in a pig head cadaver, involving 438 scans and temperature changes that caused tissue shifts.
- Results indicated significant volume changes in resection cavities and cut tissues due to temperature, with notable deformation that affects how tissues fit together post-surgery, highlighting the method's effectiveness in quantifying tissue changes.