The relationship of endothelin-1 and inducible nitric oxide synthase at several stages of the anastomotic healing process.

Aim: The aim of this study was to investigate the interaction between the endothelin-1 (ET-1) and inducible NO synthase (iNOS) in anastomotic healing.

Methods: The expression of ET-1 and iNOS were investigated by immunohistochemistry in a rat end-to-end arterial anastomotic model. The aorta of 50 male Wistar rats was exposed, then transversely divided and re-anastomosed.

Pseudoxanthoma elasticum and angioid streaks in two cases of beta-thalassaemia.

Two cases of beta thalassaemia with pseudoxanthoma elasticum and angioid streaks (Grönblad-Strandberg syndrome) are reported. To the best of our knowledge, this is the first report of a combination between these two genetically determined disorders. The possible theories of the pathogenesis of pseudoxanthoma elasticum and angioid streaks are discussed.