A study with 150 migraine patients compared the effects of metoclopramide (10 mg and 20 mg) and a placebo on nausea relief during attacks.
Nausea was relieved in 71% of the placebo group, while metoclopramide was significantly more effective, helping 86% of patients feel better (p = 0.04).
Although metoclopramide didn't reduce pain on its own, it was found to enhance the effectiveness of analgesics and sedatives, nearing statistical significance (p = 0.06).