Publications by authors named "A Adamo"
Article Synopsis
- Early detection of recurrences in gynecological cancers is vital, and circulating tumor DNA (ctDNA) analysis via liquid biopsy shows promise for monitoring disease progression.
- The study assessed the effectiveness of digital Polymerase Chain Reaction (dPCR) in detecting ctDNA in three patients with confirmed cancer relapses post-surgery, using patient-specific mutations identified through whole-exome sequencing.
- Results indicated that dPCR could detect increased ctDNA levels before traditional serum markers like CA125, but also highlighted the challenges of tumor heterogeneity, as one patient did not show ctDNA signals despite clinical signs of relapse.
Background: Pancreatic cancer (PC) is characterised by late diagnosis, tumour heterogeneity, and a peculiar immunosuppressive microenvironment, leading to poor clinical outcomes. Local ablative techniques have been proposed to treat unresectable PC patients, although their impact on activating the host immune system and overcoming resistance to immunotherapy remains elusive.
Methods: We dissected the immune-modulatory abilities triggered by local ablation in mouse and human PC models and human specimens, integrating phenotypic and molecular technologies with functional assays.
The worm , with its short lifecycle and well-known genetic and metabolic pathways, stands as an exemplary model organism for biological research. Its simplicity and genetic tractability make it an ideal system for investigating the effects of different conditions on its metabolism. The chemical analysis of this nematode was performed to identify specific metabolites produced by the worms when fed with either self- or nonself-DNA.
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- Indoleamine 2,3-dioxygenase 1 (IDO1) is important for tumors to evade the immune system, acting both as an enzyme that breaks down tryptophan and as a signaling protein that supports immunosuppression in tumors.
- Researchers aimed to find a better way to inhibit IDO1 that would disrupt its enzymatic and signaling roles, leading them to discover a compound called VS-15.
- VS-15 effectively binds to the inactive form of IDO1, blocking its activity and its interaction with other proteins, which helps improve immune responses, particularly in pancreatic cancer patients, and points to new treatment possibilities in cancer immunotherapy.
Article Synopsis
- - The study investigates the link between congenital lung malformations (CLMs) and the risk of developing cancer by examining genetic mutations in various lung malformations through whole-genome sequencing.
- - Analysis revealed that 95% of the CLMs exhibited genomic instability, with 30% harboring genetic variants associated with tumor development, suggesting a potential predisposition to malignancy.
- - The findings indicate that while CLMs are often benign, their genetic alterations, combined with environmental carcinogenic factors, may increase the likelihood of lung cancer, highlighting a significant biological connection.