Publications by authors named "A Abudayyeh"
Immune Checkpoint Inhibitor-Related Acute Kidney Injury-Management and Challenges.
Am J Nephrol
January 2025
Immune check point inhibitors (ICIs) have been increasingly used over the past decade for treatment of several cancer types. Despite the excellent cancer response they provide, their use has been associated with serious immune-related adverse events (irAEs) affecting multiple systems including the kidney. Currently, limited data is available to guide treatment of acute kidney injury secondary to ICI use (ICI-AKI) due to tubulointerstitial nephritis or glomerulonephritis.
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- High-dose methotrexate (MTX) can lead to serious complications like acute kidney injury (AKI), neutropenia, and liver damage, but glucarpidase, an enzyme that breaks down MTX, shows potential benefits.
- In a study of 708 patients with MTX-AKI across 28 cancer centers, those receiving glucarpidase had a significantly higher chance of kidney recovery and faster recovery times compared to those who did not receive the treatment.
- Additionally, glucarpidase treatment was associated with lower rates of severe neutropenia and liver enzyme elevation, but there was no notable difference in mortality rates between the two groups.
Article Synopsis
- Water contamination by oil pollutants is a significant environmental issue affecting human and marine life, prompting research into materials for oil-water separation.
- Metal-organic frameworks (MOFs) and their composites show promise due to their porous structures that can target specific phases in mixtures, but their use is limited by stability and processability issues.
- Recent advancements focus on enhancing MOFs with hydrophobic properties and incorporating them into polymer composites to improve stability, recyclability, and applicability in natural settings, while addressing ongoing challenges in the field.
Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer and are now the backbone of therapy for several malignancies. However, ICIs can cause a spectrum of kidney immune-related adverse events including acute kidney injury (AKI), most commonly manifesting as acute interstitial nephritis (AIN), although glomerular disease and electrolyte disturbances have also been reported. In this position statement by the American Society of Onco-nephrology (ASON), we summarize the incidence and risk factors for ICI-AKI, pathophysiological mechanisms, and clinicopathologic features of ICI-AKI.
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