Publications by authors named "A Abravan"
Increasing radiotherapy dose to select cardiac structures is associated with cardiac events and premature death. Previous studies have found a dose-response relationship for structures at the base of the heart. We have defined a new cardiac anatomical region at risk for radiotherapy by consensus opinion, based on image-based data-mining studies.
View Article and Find Full Text PDFBackground: Comorbidities have been shown to impact the presentation and treatment of patients with cancers. This study investigates the prevalence and patterns of comorbidity in a pan-cancer cohort of patients treated at a large UK specialist cancer center over a 9-year period.
Methods: A retrospective review of 77,149 patients from 01/01/2014 to 15/12/2022 was conducted using the Adult Comorbidity Evaluation 27 score (ACE-27) to assess the burden of comorbidities across 12 organ systems and an overall comorbidity burden.
The European SocieTy for Radiotherapy and Oncology (ESTRO) organized a one-year pilot mentoring programme. At evaluation after one year, both mentors and mentees scored the programme with a median score of 9 on a scale of 10. All of the mentors indicated that they wanted to participate again as mentors.
View Article and Find Full Text PDFArticle Synopsis
- The study examines severe radiation-induced lymphopenia (RIL) in stage III non-small cell lung cancer (NSCLC) patients undergoing chemoradiotherapy, noting its negative impact on immunotherapy outcomes and survival rates.
- It validates two prediction models developed at The Christie and MD Anderson Cancer Center for forecasting the likelihood of grade ≥3 and grade 4 lymphopenia in patients, using various patient-specific factors.
- Results showed that the MDACC model outperformed the Christie model in predicting severe lymphopenia, suggesting it is more effective for identifying high-risk patients, while calling for further development and validation of the Christie model.