Background: Treatment with sulphasalazine of patients with mild and moderate forms of Crohn's disease may result in side effects in some of them.
Case Report: An 11-year-old girl with Crohn's disease was given 40 mg/kd/day of sulphasalazine after achieving remission with prednisone. She developed urticaria and eosionophilia 8 days later, then extended skin edema during a second course of sulphasalazine requiring methyl prednisolone therapy.