Formulation and evaluation of Fluconazole Nanosuspensions: In vitro characterization and transcorneal permeability studies.

The aim in this study was to develop and evaluate a nanofluconazole (FLZ) formulation with increased solubility and permeation rate using nanosuspensions. The FLZ nanosuspensions were stabilized using a variety of stabilizing agents and surfactants in various concentrations. The FLZ nanosuspension was characterized in vitro using particle size, zeta potential, X-ray powder diffraction (XRPD), and solubility.

RNAi-mediated knockdown of papilin gene affects the egg hatching in Nilaparvata lugens.

Background: The brown planthopper (BPH), Nilaparvata lugens, is one of the most destructive pests of rice. Owing to the rapid adaptation of BPH to many pesticides and resistant varieties, identifying putative gene targets for developing RNA interference (RNAi)-based pest management strategies has received much attention for this pest. The glucoprotein papilin is the most abundant component in the basement membranes of many organisms, and its function is closely linked to development.

Reliability constrained dynamic generation expansion planning using honey badger algorithm.

Generation expansion planning (GEP) is a complex, highly constrained, non-linear, discrete and dynamic optimization task aimed at determining the optimum generation technology mix of the best expansion alternative for long-term planning horizon. This paper presents a new framework to study the GEP in a multi-stage horizon with reliability constrained. GEP problem is presented to minimize the capital investment costs, salvage value cost, operation and maintenance, and outage cost under several constraints over planning horizon.

Tissue-specific regulation of volatile emissions moves predators from flowers to attacked leaves.

Plant-predator mutualisms have been widely described in nature. How plants fine-tune their mutualistic interactions with the predators they recruit remains poorly understood. In the wild potato (Solanum kurtzianum), predatory mites, Neoseiulus californicus, are recruited to flowers of undamaged plants but rapidly move downward when the herbivorous mites, Tetranychus urticae, damage leaves.

Metabolic reprogramming by immune-responsive gene 1 up-regulation improves donor heart preservation and function.

Preservation quality of donor hearts is a key determinant of transplant success. Preservation duration beyond 4 hours is associated with primary graft dysfunction (PGD). Given transport time constraints, geographical limitations exist for donor-recipient matching, leading to donor heart underutilization.