Publications by authors named "A Abdel Samie"
Impact of Postsynthetic Modification on the Covalent Organic Framework (COF) Structures.
ACS Appl Mater Interfaces
November 2024
Covalent organic frameworks (COFs) have emerged as a versatile class of materials owing to their well-defined crystalline structures and inherent porosity. In the realm of COFs, their appeal lies in their customizable nature, which can be further enhanced by incorporating diverse functionalities. Postsynthetic modifications (PSMs) emerge as a potent strategy, facilitating the introduction of desired functionalities postsynthesis.
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- The study focuses on the impact of persistent bacterial gastroenteritis in children, revealing that 45.5% of participants experienced at least one persistent episode during the research period.
- Persistent infections were defined as three or more consecutive months of positive test results, with affected children showing an average of 150 days of positive symptoms.
- While persistent infections did not significantly affect short-term weight gain, they were linked to a decrease in linear growth over nine months, indicating a serious health risk for young children.
Article Synopsis
- The study investigates factors contributing to high under-five mortality rates in Punjab, Pakistan, focusing on demographic, socioeconomic, and environmental influences.
- Data was collected from a 2017-18 survey, analyzing responses from 39,024 children aged 0-59 months, using statistical methods to explore relationships between variables.
- Findings indicate that maternal education significantly reduces child mortality, and improving access to safe drinking water could further decrease mortality rates, especially in low-income households.
According to the BCS classification system, the differentiation of drugs is based on two essential parameters of solubility and permeability, meaning the latter is as pivotal as the former in creating marketable pharmaceutical products. Nevertheless, the indispensable role of permeability in pharmaceutical cocrystal profiles has not been sufficiently cherished, which can be most probably attributed to two principal reasons. First, responsibility may be on more user-friendly measurement procedures for solubility compared to permeability, implying the permeability measurement process seems unexpectedly difficult for researchers, whereas they have a complete understanding of solubility concepts and experiments.
View Article and Find Full Text PDFStimuli-Responsive Covalent Organic Frameworks for Cancer Therapy.
ACS Appl Mater Interfaces
October 2024
Chemotherapy as a common anticancer therapeutic modality is often challenged by various obstacles such as poor stability, low solubility, and severe side effects of chemotherapeutic agents as well as multidrug resistance of cancerous cells. Nanoparticles in the role of carriers for chemotherapeutic drugs and platforms for combining different therapeutic approaches have effectively participated in overcoming such drawbacks. In particular, nanoparticles able to induce their therapeutic effect in response to specific stimuli like tumor microenvironment characteristics (e.
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