Publications by authors named "A Abchee"
Article Synopsis
- Severe coronary artery disease (CAD) is linked to serious complications like heart attacks and angina, and this study focuses on understanding the genetic factors associated with severe and multi-vessel CAD.
- Researchers analyzed data from 1,900 patients with severe CAD and 1,056 healthy controls, identifying 14 genetic variants related to severe disease and finding specific associations based on age.
- Notably, the PHACTR1 gene variant increases the risk for younger individuals, while another variant in APOC1/APOE decreases risk for older adults, highlighting how genetic differences can influence CAD severity and potentially inform personalized treatment strategies.
Background: Type 2 Diabetes (T2D) is influenced by genetic, environmental, and ageing factors. Ageing pathways exacerbate metabolic diseases. This study aimed to examine both clinical and genetic factors of T2D in older adults.
View Article and Find Full Text PDFAims: Type 2 diabetes (T2D) and coronary artery disease (CAD) often coexist and share genetic factors.This study aimed to investigate the common genetic factors underlying T2D and CAD in patients with CAD.
Methods: A three-step association approach was conducted: a) a discovery step involving 943 CAD patients with T2D and 1,149 CAD patients without T2D; b) an eliminating step to exclude CAD or T2D specific variants; and c) a replication step using the UK Biobank data.
Background And Objectives: High homocysteine levels are associated with increased risk of hypertension and stroke. Homocysteine is metabolized by the methylenetetrahydrofolate reductase (). We aimed to investigate the levels of homocysteine and their association with hypertension, stroke, and antihypertensive medication usage in patients with different C677T genotypes.
View Article and Find Full Text PDFArticle Synopsis
- Coronary artery disease (CAD) leads to many deaths globally and standard treatments like stent placement and bypass surgery can fail long-term due to restenosis.
- * A study with 5,242 patients examined risk factors for restenosis, focusing on diabetes, hypertension, and dyslipidemia, applying statistical models to analyze data.
- * Findings revealed dyslipidemia and type 2 diabetes increase restenosis risk, with specific genetic variants (rs9349379 and rs264) linked to heightened risk, particularly among women and diabetic patients.