[Values and limitations of radioimmunoscintigraphy with MoAb 225-28S in the diagnosis of posterior uveal melanoma].

When evaluating a clinical situation in which a posterior uveal melanoma (PUM) is suspected, we have to use all available diagnostic procedures because it may be difficult to distinguish between amelanotic tumours and/or small melanomas. Early diagnosis of a small lesion is mandatory for successful conservative therapy. Radioimmunoscintigraphy (RIS) of malignant melanoma has become an encouraging tool in Nuclear Medicine.

Possible relations between sensitivity to phenylthiocarbamide and goiter.

Taste sensitivity to phenylthiocarbamide (PTC) using the Harris-Kalmus method was studied in 193 patients with thyroid disease and in a control sample of 311 individuals living in the Emilia area of Italy. The patients were classified according to the morphology of struma (mononodular, polynodular, diffuse) and to the toxic and nontoxic forms of goiter. Eighteen percent were nontasters in the control sample; 37.

Multicenter study of immunoscintigraphy with radiolabeled monoclonal antibodies in patients with melanoma.

A multicenter study was performed to analyze the efficacy of 99mTc- and 111In-labeled F(ab')2 fragments of monoclonal antibody (MoAb) 225.28S (reactive with a high molecular weight melanoma associated antigen) to radioimage malignant lesions in patients with melanoma. A total of 254 melanoma patients, carrying 412 documented melanoma lesions, were studied in 10 nuclear medicine departments.