A surrogate ELISA to select high titer human convalescent plasma for treating immunocompromised patients infected with SARS-CoV-2 variants of concern.

Background: The emergence of new SARS-CoV-2 variants poses a new challenge for the treatment of immunocompromised patients against COVID-19. In this context, high titer COVID-19 Convalescent Plasma (CCP) is one of the few available therapeutics for these patients. We have revisited the selection of CCP samples and its efficacy against Omicron XBB.

Uncovering functional lncRNAs by scRNA-seq with ELATUS.

Long non-coding RNAs (lncRNAs) play fundamental roles in cellular processes and pathologies, regulating gene expression at multiple levels. Despite being highly cell type-specific, their study at single-cell (sc) level is challenging due to their less accurate annotation and low expression compared to protein-coding genes. Here, we systematically benchmark different preprocessing methods and develop a computational framework, named ELATUS, based on the combination of the pseudoaligner Kallisto with selective functional filtering.

Ash Interaction with Two Cu-Based Magnetic Oxygen Carriers during Biomass Combustion by the Chemical Looping with Oxygen Uncoupling Process.

Chemical-looping combustion (CLC) stands out as a promising method for carbon capture and storage for the purpose of mitigating climate change. The process involves the conversion of fuel facilitated by an oxygen carrier, with the resulting CO inherently separated from other air components. Notably, when applied to biomass combustion this process offers a pathway to achieving negative CO emissions.