Publications by authors named "A ABDEL-MALEK"

The continuous requirement to substitute safe and affordable alternatives for helminth medications, as well as address the resistance of some used drug classes, introduced bioactive products derived from marine animals into the field of competition; however, almost all the previous research only focused on their impact on bacterial and protozoal infection. In the present work, we investigated the potential in vitro nematocidal effect of the aqueous extract of defense secretions for four species of marine mollusks: two cephalopods, namely the cuttlefish Sepia pharaonis and the common Octopus Octopus vulagris and two gastropods, the sea hare Aplysia argus and the sea slug Berthillina citrina, against the adult murine pinworm Syphacia obvelata. Data showed dose and time efficacy in all examined extracts.

View Article and Find Full Text PDF

Background: Several studies have been reported previously on the bioactivities of different extracts of marine molluscs. Therefore, we decided to evaluate the cytotoxic and antimicrobial activities of S. pharaonis ink as a highly populated species in the Red Sea.

View Article and Find Full Text PDF

Objective: To explore the association between intraoperative methadone use, postoperative pain, and opioid consumption after coronary artery bypass grafting (CABG) surgery.

Design: Retrospective cohort study.

Setting: Single academic medical center.

View Article and Find Full Text PDF

Schistosomiasis is the second most prevailing parasitic disease worldwide. Although praziquantel is considered an effective drug in the treatment against schistosomiasis to some extent, there is an emerging drug resistance that widely recorded. Therefore, there is an urgent need to develop effective and safe anti-schistosomal drugs.

View Article and Find Full Text PDF