Publications by authors named "A A de Wit"
Immune checkpoint inhibitor (ICI) treatment has proven successful for advanced melanoma, but is associated with potentially severe toxicity and high costs. Accurate biomarkers for response are lacking. The present work is the first to investigate the value of deep learning on CT imaging of metastatic lesions for predicting ICI treatment outcomes in advanced melanoma.
View Article and Find Full Text PDFFlow-driven pattern formation during coacervation of xanthan gum with a cationic surfactant.
Phys Chem Chem Phys
December 2024
We experimentally demonstrate that the coacervation of a biopolymer can trigger a hydrodynamic instability when a coacervate is formed upon injection of a xanthan gum dispersion into a cationic surfactant (CTAB) solution. The local increase of the viscosity due to the coacervate formation induces a viscous fingering instability. Three characteristic displacement regimes were observed: a viscous fingering dominated regime, a buoyancy-controlled "volcano" regime and a "fan"-like regime determined by the coacervate membrane dynamics.
View Article and Find Full Text PDFOscillatory kinetics coupled to diffusion can produce traveling waves as observed in physical, chemical, and biological systems. We show experimentally that the properties of such waves can be controlled by fluid stretching and compression in a hyperbolic flow. Localized packet waves consisting in a train of parallel waves can develop due to a balance between diffusive broadening and advective compression along the unstable manifold.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on detecting multijet signatures from proton-proton collisions at a high energy of 13 TeV, analyzing a dataset totaling 128 fb^{-1}.
- A special data scouting method is utilized to pick out events with low combined momentum in jets.
- This research is pioneering in its investigation of electroweak particle production in R-parity violating supersymmetric models, particularly examining hadronically decaying mass-degenerate higgsinos, and it broadens the limits on the existence of R-parity violating top squarks and gluinos.
Objective: We aim to clarify potential risk factors of complications after uterine artery embolisation (UAE).
Setting: Complications after uterine artery embolisation (UAE) for symptomatic fibroids are rare, but failure of treatment occurs for approximately 13%-24% of patients at 10 years.
Design: We conducted a case-control study including all complications post UAE over 15 years in our specialised unit.