Publications by authors named "A A de Smet"
Microbiome analysis has become a crucial tool for basic and translational research due to its potential for translation into clinical practice. However, there is ongoing controversy regarding the comparability of different bioinformatic analysis platforms and a lack of recognized standards, which might have an impact on the translational potential of results. This study investigates how the performance of different microbiome analysis platforms impacts the final results of mucosal microbiome signatures.
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- Many patients remain dissatisfied after total knee arthroplasty (TKA), leading to interest in personalized alignment strategies to enhance satisfaction and function.
- This study compared patient outcomes between those with limb overcorrection and a control group, finding that the overcorrection group had better satisfaction and functional scores.
- The study concluded that accidental limb overcorrection does not negatively impact clinical outcomes or patient satisfaction in the midterm, and an optimal alignment target wasn't determined.
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- Human myxovirus resistance 2 (MX2) inhibits HIV-1 and herpesviruses post-entry by interacting with viral capsids.
- Researchers identified that MX2 interacts with numerous FG-rich proteins and forms multiprotein condensates essential for its antiviral activity.
- These condensates trap the viral capsids and disrupt their entry into the nucleus, effectively preventing the viruses from delivering their genomes into host cells.
Identification of risk factors for race day injury can improve greyhound welfare. Race day fractures are the most significant injury event and have the greatest negative impact on dog welfare and the industry's social license to operate. This study aimed to describe the incidence and risk factors for race-related fractures in greyhounds racing in Western Australia.
View Article and Find Full Text PDFBackground And Aims: Mucosal healing is considered as a key therapeutic endpoint in inflammatory bowel diseases (IBD) and comprises endoscopic improvement of inflammation without taking barrier healing into account. Mucins are critical components of the mucosal barrier function that give rise to structurally diverse isoforms. Unraveling disease-associated mucin isoforms that could act as an indication for barrier function would greatly enhance IBD management.
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