Publications by authors named "A A de Couto"

Introduction: Mozambique is among the highest-burden countries for drug-resistant tuberculosis in the world. However, the spatial distribution of drug-resistant tuberculosis, in the country is unknown. Therefore, we aimed to analyse the spatial distribution, predictors, and hotspot districts for drug-resistant tuberculosis incidence in Mozambique.

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The 18-exon human gene codes for dual-activity triokinase and FMN cyclase (TKFC) in an ORF, spanning from exon 2 to exon 18. In addition to TKFC-coding transcripts (classified as type by their intron-17 splice), databases contain evidence for alternative transcripts, but none of them has been expressed, studied, and reported in the literature. A novel full-ORF transcript was cloned from brain cDNA and sequenced (accession no.

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How do neural circuits accommodate changes that produce cognitive variation? We explore this question by analyzing the evolutionary dynamics of an insect learning and memory circuit centered within the mushroom body. Mushroom bodies are composed of a conserved wiring logic, mainly consisting of Kenyon cells, dopaminergic neurons, and mushroom body output neurons. Despite this conserved makeup, there is huge diversity in mushroom body size and shape across insects.

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Article Synopsis
  • Sjögren's disease is a chronic autoimmune condition primarily causing dry mouth and eyes, alongside other symptoms.
  • It involves reduced saliva production and changes in the quality of mucins, which are essential for mouth and eye hydration.
  • A protein called Giantin is mislocalized in the salivary glands of Sjögren’s patients, disrupting its interaction with enzymes that modify mucins, potentially explaining decreased mucin sulfation in these individuals.
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