Publications by authors named "A A Zvyagin"
The application of circulating tumor cells (CTCs) as diagnostic and prognostic markers in oncology is gaining increasing importance in clinical practice. Currently, various methods exist for detecting CTCs in patients' biological fluids. This systematic review aimed to compare the efficacy of different techniques for isolating and detecting CTCs from blood, against the FDA-cleared CellSearch® technology, in breast cancer patients.
View Article and Find Full Text PDFTargeted drug delivery for primary brain tumors, particularly gliomas, is currently a promising approach to reduce patient relapse rates. The use of substitutable scaffolds, which enable the sustained release of clinically relevant doses of anticancer medications, offers the potential to decrease the toxic burden on the patient's organism while also enhancing their quality of life and overall survival. Upconversion nanoparticles (UCNPs) are being actively explored as promising agents for detection and monitoring of tumor growth, and as therapeutic agents that can provide isolated therapeutic effects and enhance standard chemotherapy.
View Article and Find Full Text PDFDiabetic peripheral neuropathy (DPN) is a prevalent complication of diabetes mellitus (DM), significantly contributing to the risk of amputation and mortality. Reactive oxygen species (ROS) can induce both neurological and structural harm through direct impact and pyroptosis, underscoring the critical role of ROS regulation in mitigating DPN. In this research endeavor, we propose harnessing the inherent antioxidant properties of sulfhydryl groups by grafting them onto gold nanodots through an amidation reaction, resulting in the creation of ROS-responsive AuNDs.
View Article and Find Full Text PDFArticle Synopsis
- - The study highlights advancements in diagnosing gluten intolerance, emphasizing the importance of accurate testing while maintaining a strict gluten-free diet (GFD) as the primary treatment despite nutritional challenges it may pose.
- - It explores the nutritional benefits of incorporating amaranth products into a GFD, noting its high protein content and favorable lipid profile, making it a suitable option for children with gluten intolerance.
- - Research findings suggest that using amaranth flour instead of corn starch in gluten-free bread significantly boosts protein and fiber levels without compromising taste, showcasing its potential in improving dietary therapy for those with gluten intolerance.
Article Synopsis
- * A new multifunctional supramolecular hyaluronic acid hydrogel dressing (GHPM) has been developed, showcasing properties like excellent tissue adhesion, antibacterial action, conductivity, and antioxidant capabilities, while also maintaining injectable and self-healing functions.
- * Treatment with the GHPM hydrogel accelerates wound healing by preventing infections and promoting collagen deposition, especially when combined with electrical stimulation, which enhances angiogenesis and neurogenesis for better overall recovery.