Cultured meat platform developed through the structuring of edible microcarrier-derived microtissues with oleogel-based fat substitute.

With the increasing global demand for meat, cultured meat technologies are emerging, offering more sustainable solutions that aim to evade a future shortage of meat. Here, we demonstrate a cultured meat platform composed of edible microcarriers and an oleogel-based fat substitute. Scalable expansion of bovine mesenchymal stem cells on edible chitosan-collagen microcarriers is optimized to generate cellularized microtissues.

Mode of Action of RZL-012, a New Fat-Reducing Molecule.

Background: RZL-012 (5-[3,6-dibromo-9H-carbazol-9-yl]-N,N,N-trimethylpentan-1-aminium chloride) is a novel investigational drug injected subcutaneously into fat tissues in patients with fat-related disorders (Dercum disease) or subjects seeking aesthetic changes.

Objective: Preclinical studies were undertaken to understand RZL-012's mechanism of action.

Materials And Methods: The effects of RZL-012 were tested in vitro by measuring adipocyte cell killing, membrane integrity, cytosolic calcium, and mitochondrial membrane potential (MMP).

The Impact of Global Development Pathways on Food Security and Diet Quality: Results of a Global Economic Model.

This study aims to assess the impact of future global development pathways on food and nutrition security, particularly on the composition of diets considering macronutrients. For this purpose, two alternative baseline scenarios until 2030 following the narratives of shared socioeconomic pathways are simulated using a global economic model, extended to account for detailed nutrition information of different food groups taken from the FAO food balance sheets. In general, both scenarios reveal increases in energy intake for the average consumer in all regions.

Evaluation of eliciting activity of peptidil prolyl cys/trans isomerase from encapsulated in sodium alginate regarding plant resistance to viral and fungal pahogens.

Use of chemical pesticides poses a threat for environment and human health, so green technologies of crop protection are of high demand. Some microbial proteins able to activate plant defense mechanisms and prevent the development of resistance in plant pathogens, may be good alternative to chemicals, but practical use of such elicitors is limited due to need to protect them against adverse environment prior their delivery to target receptors of plant cells. In this study we examined a possibility to encapsulate heat resistant FKBP-type peptidyl prolyl cis-trans isomerase (PPIase) from , which possesses a significant eliciting activity in relation to a range of plant pathogens, in sodium alginate microparticles and evaluated the stability of resulted complex under long-term UV irradiation and in the presence of proteinase K, as well as its eliciting activity in three different "plant-pathogen" models comparing to that of free PPIase.