Publications by authors named "A A Wurm"
Article Synopsis
- The European LeukemiaNet (ELN) updated its risk classification for acute myeloid leukemia (AML) patients in 2022 (ELN22) and a study evaluated its effectiveness on 1,570 newly diagnosed patients.
- Compared to the previous 2017 classification (ELN17), the new ELN22 showed a similar distribution of risk categories but reclassified 22% of patients, mostly into intermediate or adverse groups, resulting in better prognostic accuracy, particularly for overall survival (OS).
- The study found significant differences in survival rates based on specific gene mutations within the adverse risk group, highlighting the need for tailored treatment approaches based on genetic factors.
Osteomyelitis is a bone disease caused by bacteria that can damage bone. Raman handheld spectroscopy has emerged as a promising diagnostic tool for detecting bone infection and can be used intraoperatively during surgical procedures. This study involved 120 bone samples from 40 patients, with 80 samples infected with either or Raman handheld spectroscopy demonstrated successful differentiation between healthy and infected bone samples and between the two types of bacterial pathogens.
View Article and Find Full Text PDFAbout 25% of melanoma harbor activating NRAS mutations, which are associated with aggressive disease therefore requiring a rapid antitumor intervention. However, no efficient targeted therapy options are currently available for patients with NRAS-mutant melanoma. MEK inhibitors (MEKi) appear to display a moderate antitumor activity and also immunological effects in NRAS-mutant melanoma, providing an ideal backbone for combination treatments.
View Article and Find Full Text PDFComparison of Mid-Infrared Handheld and Benchtop Spectrometers to Detect in Bone Grafts.
Bioengineering (Basel)
August 2023
Bone analyses using mid-infrared spectroscopy are gaining popularity, especially with handheld spectrometers that enable on-site testing as long as the data quality meets standards. In order to diagnose in human bone grafts, this study was carried out to compare the effectiveness of the Agilent 4300 Handheld Fourier-transform infrared with the Perkin Elmer Spectrum 100 attenuated-total-reflectance infrared spectroscopy benchtop instrument. The study analyzed 40 non-infected and 10 infected human bone samples with , collecting reflectance data between 650 cm and 4000 cm, with a spectral resolution of 2 cm (Agilent 4300 Handheld) and 0.
View Article and Find Full Text PDFArticle Synopsis
- Targeted therapies for cancer rely on pinpointing specific weaknesses within tumors.
- Utilizing small RNA sequencing, the study reveals that microRNAs (miRNAs) that typically inhibit activated cancer pathways are often reduced.
- The researchers developed a method that uses low miRNA expression levels to identify potential drug targets and validate this approach across various cancer models, ultimately showing its effectiveness in guiding treatment decisions based on cancer vulnerabilities.