Publications by authors named "A A Varlamov"
Electrolysis of -alkynyl--(formyl)anilides and sodium sulfinates on graphite electrodes delivers biologically sound 3-(sulfonyl)quinol-4-ones with moderate to good yields. The reaction is carried out in an undivided cell in the presence of silver(I) oxide with potassium iodide or sodium tetrafluoroborate as the supporting electrolyte. The reaction tolerates variously substituted anilides as well as aryl and alkyl sulfinates.
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- The diagnosis of thyroid gland tumors is complicated, requiring specialized expertise and significant time, especially when analyzing many whole slide images from one patient.
- This paper explores using artificial intelligence, specifically a Multiple-Instance Learning model, trained on weak patient-level data from over 1100 patients to differentiate between benign and malignant cases, achieving a notable F1-Score of 0.85.
- The study highlights challenges in using real-world data, such as potential issues that could lead to model overfitting, and emphasizes that detailed annotations improve accuracy, especially in smaller datasets.
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- * The complexity in synthesizing these benzazecine structures has limited their study in organic and medicinal chemistry, despite their promising pharmacological activities.
- * This review highlights recent advancements in the synthetic methods for arene-fused azecine derivatives and their potential as versatile drug scaffolds, particularly for developing treatments for mental disorders, cancer, and neurodegenerative diseases.
Previous studies have shown that some lamellarin-resembling annelated azaheterocyclic carbaldehydes and related imino adducts, sharing the 1-phenyl-5,6-dihydropyrrolo[2,1-]isoquinoline (1-Ph-DHPIQ) scaffold, are cytotoxic in some tumor cells and may reverse multidrug resistance (MDR) mediated by P-glycoprotein (P-gp). Herein, several novel substituted 1-Ph-DHPIQ derivatives were synthesized which carry carboxylate groups (COOH, COOEt), nitrile (CN) and Mannich bases (namely, morpholinomethyl derivatives) in the C2 position, as replacements of the already reported aldehyde group. They were evaluated for antiproliferative activity in four tumor cell lines (RD, HCT116, HeLa, A549) and for the ability of selectively inhibiting P-gp-mediated MDR.
View Article and Find Full Text PDFHere, An efficient approach to obtaining previously unknown furo[2',3':2,3]pyrrolo[2,1-]isoquinoline derivatives from readily available 1-R-1-ethynyl-2-vinylisoquinolines is described. The reaction features a simple procedure, occurs in hexaflouroisopropanol and does not require elevated temperatures. It has been found that the addition of glacial acetic acid significantly increases the yields of the target spirolactone products.
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