Dihydrosamidin: the basic khellactone ester derived from and its impact on neurotrophic factors, energy and antioxidant metabolism after rat cerebral ischemia-reperfusion injury.

Dihydrosamidin (DHS), a khellactone 3'--isovaleroyl-4'--acetyl ester, is naturally found in Apiaceae plants yet remains underexplored in biomedical research. Employing HPLC-PDA-MS analysis, the profiling of coumarins in revealed its significant presence, reaching DHS concentrations of 95 mg/g. DHS administering at a dosage of 80 mg/kg during bilateral transient occlusion of the common carotid artery in Wistar rats prevented neuronal death and decreased neuron-specific enolase levels in the blood serum, increases neurotrophic factors and vascular endothelial growth factor A levels in brain lysate.

SMILES-based QSAR virtual screening to identify potential therapeutics for COVID-19 by targeting 3CL and RdRp viral proteins.

The COVID-19 pandemic has prompted the medical systems of many countries to develop effective treatments to combat the high rate of infection and death caused by the disease. Within the array of proteins found in SARS-CoV-2, the 3 chymotrypsin-like protease (3CL) holds significance as it plays a crucial role in cleaving polyprotein peptides into distinct functional nonstructural proteins. Meanwhile, RNA-dependent RNA polymerase (RdRp) takes center stage as the key enzyme tasked with replicating the viral genomic RNA within host cells.

Models for the No-Observed-Effect Concentration (NOEC) and Maximal Half-Effective Concentration (EC50).

Typical in silico models for ecotoxicology focus on a few endpoints, but there is a need to increase the diversity of these models. This study proposes models using the NOEC for the harlequin fly () and EC50 for swollen duckweed () for the first time. The data were derived from the EFSA OpenFoodTox database.

Return to Work Trajectories of Swedish Employees on Sick-Leave Due to Common Mental Disorders.

Objectives: Recent research has emphasized that return to work (RTW) is a dynamic, gradual and often uneven process with a great degree of individual variation. This study aimed to identify RTW trajectories of Swedish employees on sick-leave due to common mental disorders (CMDs). The second aim was to explore which demographic, employment, health-related and work environment characteristics predicted RTW trajectory membership.