THE INFLUENCE OF THE Chd1 CHROMATIN ASSEMBLY AND REMODELING FACTOR MUTATIONS ON DROSOPHILA POLYTHENE CHROMOSOME ORGANIZATION.

Chromatin assembly is a fundamental process that is essential for chromosome duplication subsequent to DNA replication. In addition, histone removal and incorporation take place constantly throughout the cell cycle in the course of DNA-utilizing processes, such as transcription, damage repair or recombination. In vitro chromatin assembly requires the concerned action of histone chaperones and ATP-utilizing chromatin assembly factors.

[Changes of regional hemodynamics and microcirculation in patients with obliterating atherosclerosis in stage of chronic critical ischemia of the lower extremities before and after of restorational operation performance].

The state of regional hemodynamics and microcirculation in 47 patients with obliterating atherosclerosis of the lower extremities vessels in stage of chronic critical ischemia before and after performance of restorational operation was studied up. Ileo-femoral shunting using synthetic prosthesis was done in 9 patients and femoro-popliteal shunting--in 38. In 46 patients, in whom before the operation, basing on the Doppler flowmetry data, the preservation of the microcirculation bed functional reserves was noted, after the operation the increase of the regional blood flow and microcirculation indexes was observed beginning from the first up to the fifth day.

[The significance of laser Doppler flowmetry for the prognosis and outcome evaluation of lumbar sympathectomy in patients with obliterating vascular arteriosclerosis of lower extremities].

The microcirculation state in lower extremities was studied using laser Doppler flowmetry in 37 patients with obliterating atherosclerosis before and after lumbar sympathectomy performance. It was established that laser Doppler flowmetry may be applied for estimation of the microcirculation bed functional state and prognosis of the lumbar sympathectomy results.

[Catheterization of the subclavian vein in patients with combined trauma in emergency situations].

The authors describe a simplified method of catheterization of the subclavian vein available in all medical institutions and in any situation.