Alterations in cardiac function correlate with a disruption in fatty acid metabolism in a mouse model of SMA.

Spinal Muscular Atrophy is an autosomal dominant disease caused by mutations and deletions within the SMN1 gene, with predominantly childhood onset. Although primarily a motor neuron disease, defects in non-neuronal tissues are described in both patients and mouse models. Here, we have undertaken a detailed study of the heart in the Smn2B/- mouse models of SMA, and reveal a thinning of the ventriclar walls as previously described in more severe mouse models of SMA.

The Impact of Resistance Training and Diabetes Education on Physical Functioning, Frailty Status, and Glycemia in Older Adults with Short- and Long-Duration Type 2 Diabetes: A Secondary Analysis of the Band-Frail Study.

Background: Diabetes duration is an underappreciated risk factor in type 2 diabetes (T2DM) management that can increase the risk of complications and potentially decrease the effectiveness of lifestyle interventions. However, whether T2DM duration impacts the efficacy of an elastic band resistance training intervention for older adults living with comorbid T2DM and frailty is unclear.

Objective: This analysis aimed to investigate the impact of a 16-week elastic band resistance training and diabetes education intervention on physical functioning, glycemia, and frailty in older adults of different T2DM durations.