New Amphiphilic Terpolymers of N-Vinylpyrrolidone with Acrylic Acid and Triethylene Glycol Dimethacrylate as Promising Drug Delivery: Design, Synthesis and Biological Properties In Vitro.

The terpolymers of N-vinylpyrrolidone (VP) with acrylic acid and triethylene glycol methacrylate were synthesized with more than 90% yield by radical copolymerization in ethanol from monomeric mixtures of different molar composition (98:2:2, 95:5: 2 and 98:2:5) and their monomer composition, absolute molecular masses and hydrodynamic radii in aqueous media were determined. Using the MTT test, these terpolymers were established to be low toxic for non-tumor Vero cells and HeLa tumor cells. Polymer compositions of hydrophobic dye methyl pheophorbide a (MPP) based on studied terpolymers and linear polyvinylpyrrolidone (PVP) were obtained and characterized in water solution.

Resonant electron capture by polycyclic aromatic hydrocarbon molecules: Effects of aza-substitution.

Resonant electron capture by aza and diaza derivatives of phenanthrene (7,8-benzoquinoline and 1,10-phenanthroline) and anthracene (acridine and phenazine) at incident free electron energies (Ee) in the range of 0-15 eV was studied. All compounds except 7,8-benzoquinoline form long-lived molecular ions (M-) at thermal electron energies (Ee ∼ 0 eV). Acridine and phenazine also form such ions at epithermal electron energies up to Ee = 1.

[First experience of 3D-laparoscopy in donor nephrectomy].

Objective: To assess the first experience of 3D imaging for laparoscopic donor nephrectomy.

Material And Methods: The study included 28 laparoscopic donor nephrectomies and 28 subsequent transplantations to related recipients. Of these, 14 laparoscopic donor nephrectomies were performed using 3D camera.

New Nanosized Systems Doxorubicin-Amphiphilic Copolymers of -Vinylpyrrolidone and (Di)methacrylates with Antitumor Activity.

Nanosized systems of DOX with antitumor activity on the base of micelle-like particles of amphiphilic thermosensitive copolymers of -vinylpyrrolidone (VP) with triethylene glycol dimethacrylate (TEGDM), and -vinylpyrrolidone and methacrylic acid (MAA) with TEGDM were explored. They were investigated in aqueous solutions by electron absorption spectroscopy, dynamic light scattering and cyclic voltammetry. Experimental data and quantum-chemical modeling indicated the formation of a hydrogen bond between oxygen-containing groups of monomer units of the copolymers and H-atoms of OH and NH groups of DOX; the energies and H-bond lengths in the considered structures were calculated.

[Combined therapy of acute and recurrent cystitis in women].

Lower urinary tract infection (LUTI) is one of the most common causes for a large number of females of different ages to visit a urologist and other physicians. LUTI is often a chronic condition, and its symptoms can sometimes persist throughout live, leading to a serious deterioration in the quality of life. Three clinical cases of the effective treatment of women with recurrent UTI with Phytolysin paste* and Phytolysin capsules as part of combined therapy are presented in the article.