[Selective action of chorionic gonadotropin on lymphocyte subpopulations].

Influence of chorionic gonadotropin on induction and formation of specific T-suppressors, TDTH-effectors and spontaneous killer cells, depending on its doses and schema of injections was studied. It is shown that chorionic gonadotropin has a stimulating effect on precursors of T-suppressors, not affecting the mature specific T-suppressors, causes damage to the TDTH-effectors and spontaneous killer cells, that permits chorionic gonadotropin to be recognized as an immunomodulating agent.

[Effect of B-activin on human T-suppressors].

B-activin blocks the effect of concanavalin A-induced human T-suppressors, without influencing the process of their induction.

[Effect of purine derivatives on regeneration and the immunologic reactivity of animals].

The effect of azathioprine and of KI-7 (the new purine derivative) on the immunogenesis and regeneration in mammals was studied comparatively, KI-7 with a lesser toxicity than azathioprine proved to suppress the synthesis of antibodies to the SRBC in mice in case of administration of the preparation one day before or on the day of immunization; it also considerably prolonged the survival of skin allografts in rabbits in comparison with control. At the same time it was shown that under conditions of suppression of the immunogenesis system hepatic regeneration did occur in rats, but the correlation of the proliferation processes and cellular hypertrophy differed from that under ordinary restoration conditions, depending on the immunodepressor used. Thus, in difference from azathioprine, KI-7 not only inhibited the mitotic activity of the regenerating liver, but even stimulated it somewhat.