Publications by authors named "A A Skalny"
Copper (Cu) is essential for brain development and function, yet its overload induces neuronal damage and contributes to neurodegeneration and other neurological disorders. Multiple studies demonstrated that Cu neurotoxicity is associated with mitochondrial dysfunction, routinely assessed by reduction of mitochondrial membrane potential. Nonetheless, the role of alterations of mitochondrial dynamics in brain mitochondrial dysfunction induced by Cu exposure is still debatable.
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- Acrylonitrile (AN) is an organic compound that can cause neurotoxicity, but the mechanism behind this is not fully understood; HIF-1α plays a crucial role in cellular response to low oxygen levels and may help with survival.
- In lab studies, AN reduced the levels of HIF-1α and other proteins associated with cell survival and function, leading to mitochondrial damage and increased cell death.
- Treatment that activates HIF-1α (like cobalt chloride) showed protective effects against neurotoxicity, suggesting that enhancing this pathway could be a potential strategy for mitigating the harmful effects of AN exposure.
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- Kashin-Beck disease (KBD) is a condition marked by abnormal cartilage cell death, linked to exposure to T-2 toxin, and is influenced by connective tissue growth factor (CTGF).
- Researchers studied CTGF levels and apoptosis in cartilage samples from KBD patients and found that T-2 toxin exposure increases both CTGF and apoptosis markers in chondrocytes.
- Curcumin was identified as a potential treatment that can inhibit CTGF and reduce chondrocyte apoptosis, suggesting it could help prevent cartilage damage in KBD.
Manganese (Mn) is an essential trace element involved in various physiological processes, but excessive exposure may lead to toxicity. The vascular endothelium, a monolayer of endothelial cells within blood vessels, is a primary target of Mn toxicity. This review provides a comprehensive overview of the impact of Mn on vascular endothelium, focusing on both peripheral and brain endothelial cells.
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- The study investigates how a probiotic supplement affects the gut microbiota and mineral metabolism in dairy cows, building on existing contradictory data about the gut microbiome's role in mineral regulation.
- Fifteen cows were given a specific probiotic daily for a month, and their gut microbiota and serum mineral levels were analyzed using advanced sequencing and mass spectrometry techniques.
- Results showed that the probiotic improved gut microbiota diversity, increased levels of essential minerals like calcium and zinc, and altered other serum parameters, suggesting probiotics may enhance mineral nutrition in cattle, although their impact on milk production remains to be studied.