Publications by authors named "A A Sirak"
Article Synopsis
- Peste des Petits Ruminants (PPR) is a viral disease affecting primarily goats and sheep, with some controversy around its impact on atypical hosts like cattle, warranting investigation into its progression in both species.
- The study involved 32 animals (16 goats and 16 cattle) inoculated with a specific PPR virus strain, leading to significant clinical differences: goats showed typical symptoms and earlier virus detection than cattle, which displayed milder signs.
- Findings emphasize the need for further comparative pathology studies to enhance understanding of PPR virus dynamics and potential transmission pathways, which could be crucial for controlling outbreaks.
Bacillus Calmette-Guérin (BCG) is a routinely used vaccine for protecting children against that comprises attenuated . BCG can also be used to protect livestock against ; however, its effectiveness has not been quantified for this use. We performed a natural transmission experiment to directly estimate the rate of transmission to and from vaccinated and unvaccinated calves over a 1-year exposure period.
View Article and Find Full Text PDFBackground: Paratuberculosis, caused by Mycobacterium avium subsp. paratuberculosis (MAP), is a chronic progressive granulomatous enteritis mainly affecting domestic and wild ruminants worldwide. Although paratuberculosis could be prevail in Ethiopia, there is a scarcity of epidemiological data on paratuberculosis in the country.
View Article and Find Full Text PDFBovine tuberculosis (bTB) is a disease with impact on dairy productivity, as well as having the potential for zoonotic transmission. Understanding the genetic diversity of the disease agent is important for identifying its routes of transmission. Here we investigated the level of genetic diversity of isolates and assessed the zoonotic potential in risk groups of people working in bTB-infected dairy farms in central Ethiopia.
View Article and Find Full Text PDFLocal immunological responses at the site of infections, such as at the lymph nodes and lungs, do play a role in containing infection caused by (). This bovine tuberculosis (bTB) study was conducted to evaluate cellular and cytokine responses in the lymph nodes and lungs of BCG-vaccinated and non-vaccinated calves that were naturally infected with . Immunohistochemical assays were used for examination of the responses of macrophages, T cells, cytokines and chemical mediators of 40 (22 vaccinated and 18 non-vaccinated) Holstein-Friesian-zebu crossbred calves that were naturally exposed for 1 year to a known bTB positive cattle herd.
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