Zinc Preconditioning Provides Cytoprotection following Iodinated Contrast Media Exposure in In Vitro Models.

Methods: Normal human proximal renal kidney cells (HK-2) were preconditioned with either increasing doses of ZnCl or control. Following this preconditioning, cells were exposed to increasing concentrations of Iohexol 300 mg I/ml for four hours. Key outcome measures included cell survival (MTT colorimetric assay) and ROS generation (HDCFDA fluorescence assay).

Corrigendum to "Targeting HIF-1 to Prevent Renal Ischemia-Reperfusion Injury: Does It Work?".

[This corrects the article DOI: 10.1155/2018/9852791.].

Metformin may offer no protective effect in men undergoing external beam radiation therapy for prostate cancer.

Objectives: To assess whether metformin reduces radio-resistance and increases survival in men undergoing external beam radiation therapy (EBRT) for prostate cancer (PCa), and to determine its effect on hypoxia inducible factor 1-α (HIF1α).

Patients And Methods: All patients treated with curative intent with EBRT for PCa at a major cancer centre between 2000 and 2007 were included in this study. The outcome measures of time to biochemical failure (BF), metastasis, PCa-specific mortality and overall survival (OS) were analysed in those taking metformin vs those not, using competing risk and Cox regression models.

Zinc preconditioning protects against renal ischaemia reperfusion injury in a preclinical sheep large animal model.

Ischaemia-reperfusion injury (IRI) during various surgical procedures, including partial nephrectomy for kidney cancer or renal transplantation, is a major cause of acute kidney injury and chronic kidney disease. Currently there are no drugs or methods for protecting human organs, including the kidneys, against the peril of IRI. The aim of this study was therefore to investigate the reno-protective effect of Zn preconditioning in a clinically relevant large animal sheep model of IRI.

Zinc ion dyshomeostasis increases resistance of prostate cancer cells to oxidative stress via upregulation of HIF1α.

Zinc ions (Zn) are known to influence cell survival and proliferation. However the homeostatic regulation of Zn and their role in prostate cancer (PC) progression is poorly understood. Therefore the subcellular distribution and uptake of Zn in PC cells were investigated.