Publications by authors named "A A Shein"
Article Synopsis
- * Two specific bacteriophages (vB_kpnM_05 and vB_kpnP_08) were isolated from Thai wastewater and demonstrated effectiveness against a high percentage of drug-resistant K. pneumoniae strains, showing rapid replication and stability under different conditions.
- * A phage cocktail combining these two phages alongside the antibiotic amikacin exhibited enhanced antibacterial activity, preventing bacterial regrowth and highlighting a promising therapeutic approach to combat XDR K. pneumoniae infections.
Constipation poses a significant health concern affecting individuals of varying ages and geographic locations worldwide. While the impacts of numerous probiotics on constipation are well-characterized, there has been limited assessment of the potential prebiotic effects of resistant starches. We therefore conducted a randomized, double-blind and placebo-controlled, clinical trial of resistant starch type 3 (RS-3) in Thai adults with self-reported chronic constipation.
View Article and Find Full Text PDFGiven the rise of multidrug-resistant (MDR) Pseudomonas aeruginosa infections, alternative treatments are needed. Anti-pseudomonal phage therapy shows promise, but its clinical application is limited due to the development of resistance and a lack of biofilm penetration. Recently, adjuvants like CaEDTA have shown the ability to enhance the effectiveness of combined antimicrobial agents.
View Article and Find Full Text PDFArticle Synopsis
- A common pathogen linked to hospital-acquired pneumonia shows increasing resistance to key antibiotics, highlighting the need for new treatment options.
- The review examines both current and innovative therapeutic strategies, including antibiotic combination therapies which have yielded mixed results in studies.
- It also discusses emerging therapies like antimicrobial peptides, bacteriophage-based treatments, and nanoparticle therapies, emphasizing the need for further research to ensure their safety and effectiveness before being used clinically.
The global prevalence of colistin-resistant Klebsiella pneumoniae (ColRkp) facilitated by chromosomal and plasmid-mediated Ara4N or PEtN-remodeled LPS alterations has steadily increased with increased colistin usage for treating carbapenem-resistant K. pneumoniae (CRkp). Our study demonstrated the rising trend of ColRkp showing extensively and pandrug-resistant characteristics among CRkp, with a prevalence of 28.
View Article and Find Full Text PDF