Microgel Particle Collision with Smooth and Nanofiber Hydrophobic Surfaces during Three-Dimensional Printing of a Biopolymer Layer.

The impact of microgel particles onto a wall represents an elementary process that determines the one-stage production of a biopolymer layer on a nanofiber scaffold in the framework of tissue bioengineering. The formation of a microgel layer is experimentally examined on a hydrophobic uniform surface and a nonwoven polymer membrane made of vinylidene fluoride-tetrafluoroethylene copolymer. In-air microfluidics methods, namely, an external vibration disturbance on the microflow of a cross-linkable biopolymer, make it possible to form the microstructures of "beads-on-thread" with a uniform distance between microgel particles of identical size (340-480 μm, depending on the sample).

Properties and Activity of Peptide Derivatives of ACE2 Cellular Receptor and Their Interaction with SARS-CoV-2 S Protein Receptor-Binding Domain.

The aim of this work was to design and characterize peptides based on the α-helices h1 and h2 of the ACE2 receptor, forming the interaction interface between the receptor-binding domain (RBD) of the SARS-CoV-2 S protein and the cellular ACE2 receptor. Monomeric and heterodimeric peptides connected by disulfide bonds at different positions were synthesized. Solubility, RBD-binding affinity, and peptide helicity were experimentally measured, and molecular dynamics simulation was performed in various solvents.

ANATOMICAL CORRELATIONS OF THE PALATO-ALVEOLAR COMPLEXES AND MAXILLARY SINUSES IN ADULT PERSONS.

To detect the anatomical correlations between the form of the palato-alveolar complex and the shape and degree of pneumatization of the maxillary sinuses, skull frontal saw cuts obtained from 60 adult persons were studied at the level of the second molars. The form of the palato-alveolar complex was found to change significantly with the loss of teeth. Thus the palato-alveolar complex with well expressed alveolar process of the upper jaw and high palatal vault more often corresponded to the maxillarysinus of a trihedral or uncertain form with the varying degrees of pneumatization.

[MORPHOMETRIC PARAMETERS OF PALATO-ALVEOLAR COMPLEX IN ADULTS WITH DIFFERENT FORMS OF CEREBRAL AND FACIAL SKULL].

Morphometric characteristics of a palato-alveolar complex were studied in the skulls of 150 adult individuals with various shapes of a facial and cerebral skull. No statistically significant differences in the parameters of a palato-alveolar complex were established between the groups systematized by the value of their transverse-longitudinal index of the brain skull. However, the significant differences were found between the groups of skulls, selected by the value of upper facial index.

Tumor-specific contrast agent based on ferric oxide superparamagnetic nanoparticles for visualization of gliomas by magnetic resonance tomography.

The aim of this study was to create vector superparamagnetic nanoparticles for tumor cell visualization in vivo by magnetic resonance tomography. A method for obtaining superparamagnetic nanoparticles based on ferric oxide with the magnetic nucleus diameter of 12 ± 3 nm coated with BSA and forming stable water dispersions was developed. The structure and size of the nanoparticles were studied by transmissive electron microscopy, dynamic light scattering, and x-ray phase analysis.