[Transplacental IgG against measles virus in umbilical blood of neonates from various regions of Russian Federation].

Aim: Determine content of protective transplacental IgG against measles virus in umbilical blood of neonates of various regions of Russian Federation.

Materials And Methods: Umbilical blood of 1147 neonates was studied, whose mothers had not previously had measles. 672 samples among those were from neonates of Moscow and Moscow Region, 475--from Rostov-on-Don.

[Mechanisms of formation of post-vaccinal immune response in children immunized with APDT and ADT-M preparations].

Aim: Study the mechanisms of formation of cell and humoral immunity against pertussis, diphtheria and tetanus in children immunized with immunobiological preparations (APDT vaccine and ADT anatoxin).

Materials And Methods: 30 practically healthy children (6 - 9 years of age) immunized with APDT and ADT-M preparations had TLR2, TLR4 expression determined in mononuclear cells (MNC). Vaccine preparations (APDT, ADT-M, AD-M, AT) and Corynebacterium diphtheriae gravis tox+, C.

[Immunocorrection of apoptogenic effect of pertussis preparations with neutrophilokines].

Aim: Study the possibility of resistance increase of macrophages of experimental animals to apoptogenic effect of pertussis preparations with neutrophilokines.

Materials And Methods: Apoptosis was evaluated in Coulter flow cytofluorimeter after staining with propidium iodide, as well as by characteristic morphologic changes in cells stained by histological preparations and by DNA fragmentation.

Results: The studies performed showed that pertussis preparations cause apoptosis of peritoneal macrophages leading to their alteration.

[Clinical course of acute respiratory infection and the state of microbiocenosis of upper respiratory tract in pregnant women].

Aim: Evaluate clinical features of the course of acute respiratory infection (ARI) and the state of microbiocenosis of nasopharynx of pregnant women at gestational term of 14 - 26 weeks.

Materials And Methods: At the stage of outpatient therapy of ARI 49 pregnant women at the gestational term of 14 - 26 weeks were examined: group 1--27 individuals consulting at day 1 and receiving Viferon (gel) intranasally for 10 days, group 2--22 individuals consulting at day 2 - 3 and receiving Viferon (gel and suppositorium). Respiratory viral infection was diagnosed by multiplex PCR.

[State of immunity to diphtheria and tetanus in women in early postpartum period].

Aim: Study of anti-diphtheria and anti-tetanus immunity in women in early postpartum period depending on age.

Materials And Methods: Women in early postpartum period (n =139) with unknown vaccine anamnesis aged 17 to 44 years and under the supervision of Rostov-on-Don maternity hospital No. 2 were examined for the evaluation of the anti-diphtheria and anti-tetanus immunity state.