A strain-transcending anti-AMA1 human monoclonal antibody neutralizes malaria parasites independent of direct RON2L receptor blockade.

Plasmodium falciparum apical membrane antigen 1 (AMA1) binds a loop in rhoptry neck protein 2 (RON2L) during red cell invasion and is a target for vaccines and therapeutic antibodies against malaria. Here, we report a panel of AMA1-specific naturally acquired human monoclonal antibodies (hmAbs) derived from individuals living in malaria-endemic regions. Two neutralizing hmAbs engage AMA1 independent of the RON2L-binding site.

Improvement of Iron and β-Carotene Bioaccessibility in Complementary Foods: Biofortification of Local Crops With Organic Residual Products and Microorganisms.

Micronutrient deficiencies remain a great public health challenge worldwide with iron, zinc, and vitamin A being the most problematic. It has been shown that biofortification through agronomic strategies can increase their micronutrient content, but data on the bioavailability remain limited. In Senegal, consumption of cereals and legumes is high, and orange-fleshed sweet potato (OFSP), rich in β-carotene, has been introduced a decade ago.

Some Lessons From Participatory Evaluation of the COVID-19 Response in the African Region.

This summary report describes partners' experiences and reflections on responding to the COVID-19 pandemic in selected countries in the African Region. Using a common protocol for participatory evaluation and sensemaking, it communicates country partners' experiences with the COVID-19 response in Gabon, Kenya, and Senegal as well as a regional perspective from partners in the World Health Organization Regional Office for Africa (WHO AFRO). This report describes factors identified as associated with decreases (bending the curve) of new cases of COVID-19 over time, as well those associated with increases (worsening) of new cases, seen during the study period (2020-2021).

Giant cell tumor of the talus: A case report and literature review.

Introduction And Importance: Giant cell tumor is a benign primary bone tumor of mesenchymal origin that mainly affects the long bones. Involvement of the bones of the foot is rare with an incidence of 1 to 2 %. We report a case of giant cell tumor of the talus in a 36-year-old man.