Bedaquiline-pretomanid-moxifloxacin-pyrazinamide for drug-sensitive and drug-resistant pulmonary tuberculosis treatment: a phase 2c, open-label, multicentre, partially randomised controlled trial.

Background: The current tuberculosis (TB) drug development pipeline is being re-populated with candidates, including nitroimidazoles such as pretomanid, that exhibit a potential to shorten TB therapy by exerting a bactericidal effect on non-replicating bacilli. Based on results from preclinical and early clinical studies, a four-drug combination of bedaquiline, pretomanid, moxifloxacin, and pyrazinamide (BPaMZ) regimen was identified with treatment-shortening potential for both drug-susceptible (DS) and drug-resistant (DR) TB. This trial aimed to determine the safety and efficacy of BPaMZ.

Culturable Bacterial Endophytes of Wild White Poplar ( L.) Roots: A First Insight into Their Plant Growth-Stimulating and Bioaugmentation Potential.

The white poplar ( L.) has good potential for a green economy and phytoremediation. Bioaugmentation using endophytic bacteria can be considered as a safe strategy to increase poplar productivity and its resistance to toxic urban conditions.

Evaluation of the specificity of an intradermal test with recombinant tuberculosis allergen in Bacillus Calmette-Guérin-vaccinated healthy volunteers.

Introduction: The tuberculin skin test has significant limitations for use in individuals vaccinated with BCG. The presence in the genome of of the RDI region, which is absent in the genome of Mycobacterium bovis BCG and most non-tuberculous mycobacteria, made it possible to develop new skin tests, which include a skin test with a recombinant tuberculosis allergen [RTA (Diaskintest®, JSC Generium, Russia)]. Diaskintest has shown high diagnostic performance in clinical trials and in conditions of high prevalence of tuberculosis infection.

Nonlinear three-dimensional patterns of the Marangoni convection in a thin film on a poorly conducting substrate.

We investigate the dynamics of a thin liquid film that is placed atop a heated substrate of very low thermal conductivity. The direct numerical simulation of the stationary long-wave Marangoni instability is performed with the system of coupled partial differential equations. These equations were previously derived within the lubrication approximation; they describe the evolution of film thickness and fluid temperature.

Introduction to 'New trends in pattern formation and nonlinear dynamics of extended systems'.

Pattern formation is a widespread phenomenon observed in physical, chemical and biological systems. During the past decades, powerful experimental and theoretical tools for the investigation of that phenomenon have been developed. Also, the set of pattern forming system was diversified.