[Current status and perspectives for genetic consultation and prophylactic medical examination of risk groups with malignant neoplasms of the female reproductive system and breast].

It is shown as necessary to create specialized aid to cancer families in the general structure of oncological service. The results of 2-year clinical-genetic monitoring of high-risk group relative to ovarian, breast and endometrial cancer are presented.

[The role of tumor receptor status in choosing adjuvant therapy for breast cancer patients of reproductive age].

Estrogen (ER) and progesterone (PR) receptor levels were assayed in primary tumor samples from 271 premenopausal patients suffering T1,2N1M0 (stage II) breast cancer. Four clinical groups were identified according to steroid receptor levels in which results of adjuvant treatment (chemotherapy or complex treatment) were assessed. ER and PR positivity was associated with longer disease-free and overall survival.

[The medical genetic approach in the diagnosis of cancer].

Formation of registers of families afflicted by tumors of certain sites and dynamic follow-up of "healthy" members of such families is a new approach to early diagnosis and prevention of cancer. The results of a clinico-genetic study of hormone-dependent tumors of the female genitals and breast served as a basis for the development of a pattern of medico-genetic follow-up which, in turn, may facilitate integration of the above method with treatment for cancer of said and other sites.

[Metastases in the axillary lymph nodes as the first manifestation of cancer].

The paper discusses the procedures used for detecting primary tumor in 27 patients who presented with regional lymph node involvement. Both clinical data and those of the histologic and electron microscopic examination of tissue samples from the breast and involved lymph nodes were used. The examination established neoplasm in 15 cases and failed in 12.