Publications by authors named "A A Sadik"

Pancreas divisum occurs during development when the ventral and dorsal buds of the pancreas do not fuse. It is the most common congenital anomaly of the pancreas. Patients with this condition are usually asymptomatic, but almost 25% of these patients experience recurrent pancreatitis, which may progress to chronic pancreatitis.

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Article Synopsis
  • The study investigated how different concentrations of interleukin 1 beta (IL-1β) affect the behavior of human bone marrow mesenchymal stem cells (hBM-MSCs) in terms of adhesion, proliferation, and migration.
  • Results showed that low concentrations of IL-1β (up to 50 ng/ml) enhanced cell growth and movement, while higher concentrations (100 ng/ml) significantly reduced these activities.
  • The study highlights that IL-1β stimulation increases the expression of essential genes related to MSC function, potentially improving their ability to respond to injury in inflamed environments.
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Hyponatraemia is a common electrolyte disorder. For patients with severe hyponatraemia, intensive care unit (ICU) admission may be required. This will enable close monitoring and allow safe management of sodium levels effectively.

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Introduction: Historically, the requirement to produce scholarship for advancement has challenged health professions educators heavily engaged in teaching. As biomedical scientists or healthcare practitioners, few are trained in educational scholarship, and related faculty development varies in scope and quality across institutions. Currently, there is a need for faculty development and mentoring programs to support the development of these skills.

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Background: The distinctive feature of liver fibrosis is the progressive replacement of healthy hepatic cells by the extracellular matrix protein, which is abundant in collagen I and III, with impaired matrix remodeling. The activation of myofibroblastic cells enhances the fibrogenic response of complex interactions of hepatic stellate cells, fibroblasts, and inflammatory cells to produce the excessive deposition of the extracellular protein matrix. This process is activated by multiple fibrogenic mediators and cytokines, such as TNF-α and IL-1β, accompanied with a decrease in the anti-fibrogenic factor NF-κβ.

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