DNA origami vaccines program antigen-focused germinal centers.

Recruitment and expansion of rare precursor B cells in germinal centers (GCs) is a central goal of vaccination to generate broadly neutralizing antibodies (bnAbs) against challenging pathogens such as HIV. Multivalent immunogen display is a well-established method to enhance vaccine-induced B cell responses, typically accomplished by using natural or engineered protein scaffolds. However, these scaffolds themselves are targets of antibody responses, with the potential to generate competitor scaffold-specific B cells that could theoretically limit expansion and maturation of "on-target" B cells in the GC response.

Phosphorescent Isocyanide-Metal-Carboranyl Complexes of Copper(I) and Gold(I): Synthesis and Radioluminescence.

A series of (L)MX (L=isocyanide; M=Cu(I) or Au(I); X=chloride or carboranyl) complexes have been prepared. The first examples of isocyanide Cu(I) chloride complexes with 1 : 1 stoichiometry between isocyanide and CuCl are reported and structurally characterised. The photophysical properties of (RNC)AuCl and (RNC)Au(η-carboranyl) complexes have been investigated.

Higher than expected telemedicine use by racial and ethnic minority and cognitively impaired Medicare beneficiaries.

Although pandemic-era telemedicine flexibilities may have preserved access to care, concerns remain that telemedicine may have been inequitably distributed among older adults, especially those with mild cognitive impairment or dementia (MCID). As telemedicine flexibilities are set to fully expire on December 31, 2024, we aimed to examine pandemic-era and future-intended telemedicine use among older Americans to help inform post-pandemic telemedicine policy design. We hypothesized that telemedicine would be disproportionately underutilized among older adults with MCID or with racial and ethnic minority status.

Experimental Measurement and Mathematical Quantification of Fixed-Charged Density in Rat and Pig Brain Tissue.

Cerebral edema is associated with poor prognosis because brain swelling within the rigid skull raises intracranial pressure, exacerbating secondary injuries following traumatic brain injury. Brain swelling can be characterized by triphasic biomechanics, which models brain tissue as a mixture of a deformable porous solid matrix with a negative fixed-charged density (FCD), water, and monovalent counterions. When brain cells die, the intracellular FCD is exposed, attracting cations into the cells.